Diastereodivergent asymmetric Michael-alkylation reactions using chiralN,N′-dioxide/metal complexes

Diastereodivergent asymmetric Michael-alkylation reactions using chiral N,N′-dioxide/metal complexes† †Electronic supplementary information (ESI) available. CCDC 1411858, 1412691 and 1545249. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc02757e

Asymmetric Michael addition reactions of 2-silyloxyfurans catalyzed by binaphthyldiimine-Ni(II) complexes.

N,N'-Bis(2-quinolylmethylene)-1,1'-binaphthyl-2,2'-diamine-Ni(II) complex and analogous complexes were found to be efficient chiral Lewis acid catalysts for the asymmetric Michael addition reactions between 2-silyloxyfurans and 3-alkenoyl-2-oxazolidinones, for which asymmetric inductions of up to 97% ee were obtained.

Nanocrystalline MgO for asymmetric Henry and Michael reactions.

Nanomaterials with their three-dimensional structure and defined size and shape are considered to be suitable candidates for proper alignment with prochiral substrates for unidirectional introduction of reacting species to induce an asymmetric center. We herein report the design and development of a truly recyclable heterogeneous catalyst, nanocrystalline magnesium oxide, for the asymmetric Hen...

Catalytic direct asymmetric Michael reactions: taming naked aldehyde donors.

[reaction--see text] Direct catalytic enantio- and diastereoselective Michael addition reactions of unmodified aldehydes to nitro olefins using (S)-2-(morpholinomethyl)pyrrolidine as a catalyst are described. The reactions proceed in good yield (up to 96%) in a highly syn-selective manner (up to 98:2) with enantioselectivities approaching 80%. The resulting gamma-formyl nitro compounds are read...

Constructing Enantioselectivity Using Asymmetric Michael Additions

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